Table 2.

Immune reaction to drugs

Immunologic reactions	Pathogenesis	Need of sensitization	Dose dependence	Cross reactivity
Allergic reactions	Drug modified peptide derived from intracellular haptenated protein	YES	NO	Based on affinity of immune receptors
p-i reactions	Drug bind to the TCR or to HLA molecules outside of the antigen- binding groove through noncovalent interaction	NO	YES	Based on pharmacologic properties and type or HLA or TCR
Reactions by altered repertoire model	Drugs bind within the antigen- binding groove of specific HLA molecules altering the repertoire of endogenous peptide ligands	NO	YES	Based on pharmacologic properties
Pseudoallergic reactions	Reactions related to mast cell or eosinophil activation	NO	YES	Based on ligands on mast cells or eosinophils