Table 1.

Classification of drug allergies

Type of immune response	Physiopathology	Main clinical symptoms	Chronology (after the drug)
IgE mediated	Mast cell, basophil degranulation	Anaphylaxis, angioedema, urticaria, rhinitis, asthma	within 6 hours after the last intake
IgG and complement	IgG and complement-Dependent cytotoxicity	Cytopenia	5-15 days after the start
IgM or IgG and complement or FcR	Deposition of immune complexes	Vaculitis, Serum sickness	7-21 days after the start 7-8 days after the start
Th1 (IFN-γ)	Monocytes inflammation	Dermatitis	within 21 days after the start
Th2 (IL-4 and IL-5)	Eosinophilic inflammation	Maculopapular exanthema DRESS	several days after the start 2-6 weeks after the start
Cytotoxic T cells (perforin, granzyme B, FasL)	Keratinocyte death mediated by CD4 or CD8	SJS/TEN	4-28 days after the start
T cells (IL-8/CXCL8) exanthematous pustulosis	Neutrophil inflammation	Acute generalized	1 to several days