Table 2.

Classification of non-steroidal anti-inflammatory hypersensitivity for the child aged (0-10 y) paediatric population

Cross-reactivity	Type	Clinical of reaction	Chronology presentation	Proposed mechanism	Cofactors (influence)
Cross-intolerant reactions (Non-Allergic)	Non-allergic NSAID hypersensitivity (NERD, NECD, NIUAA)	Urticaria, angioedema, dyspnea, rhinitis,	Immediate, usually from minutes to several hours conjunctivitis, anaphylaxis	COX-1 inhibition after exposure	Possible
Non-cross-Intolerant reactions (Allergic)	Selective NSAID- induced urticaria/angioedema or anaphylaxis (SNIUAA)	Urticaria, angioedema, anaphylaxis	Immediate (<1 h)	IgE-mediated	Unknown
Selective NSAID-induced delayed reactions (SNIDR)	Various symptoms and organs	Delayed onset T- cell- (usually more than 24 h involved after exposure) (e.g., fixed drug eruption, SJN/TEN, nephritis)	Unknown mediated

NSAIDs, non-steroidal anti-inflammatory drugs; COX-1, cyclooxygenase 1; SJS, Stevens-Johnson syndrome; TEN, toxic epidermal necrolysis