Table 3.

Classification of non-steroidal anti-inflammatory hypersensitivity for the older paediatric population and adolescents (10-19 y)

Cross-reactivity	Type of reaction	Clinical presentation	Chronology	Mechanism	Cofactors
Cross-intolerant reactions, non allergic	NSAIDs-exacerbated respiratory disease	Bronchial obstruction, dyspnea, nasal congestion, (NERD)	minutes-hours after last intake	COX1-inhibition	Asthma, rhinosinusitis rhinorrhea
	NSAIDs-exacerbated cutaneous disease	wheals and/or angioedema (NECD)	minutes-hours after last intake	COX1-inhibition	Chronic urticaria
	NSAIDs-induced urticaria/angioedema/anaphylaxis (NIUAA)	wheals and/or angioedema and/or anaphylaxis	minutes-hours after last intake	COX1-inhibition (probably)	Unknown
Non-cross Intolerant Reactions, Allergic	Selective NSAID- induced urticaria/ angioedema or anaphylaxis (SNIUAA)	wheals and/or angioedema and/or anaphylaxis	minutes after last intake	IgE mediated	Unknown
	Selective NSAID- induced delayed reactions (SNIDR)	cutaneous and mucous reactions, complex reactions (e.g. SJS/TEN), organ-specific disorders	delayed onset (usually more than 24 hours after last intake)	T-cell mediated	Unknown