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. 2019 May 6;15(5):e1008084. doi: 10.1371/journal.pgen.1008084

Fig 10. Loss of STRA8 results in aberrant autophagosome formation and upregulation of autophagy-lysosome gene expression in fetal ovarian germ cells during the developmental window of meiotic initiation.

Fig 10

(A, B) Transmission electron microscopy images of ovarian cross sections from wild-type (A) and Stra8-deficient (B) mice at embryonic day 14.5 (E14.5) that show primordial germ cells (PGC). Arrows indicate autophagosomes. (C, D) qRT-PCR analysis of autophagy and lysosome gene expression in wild-type and Stra8-deficient fetal ovaries (C) and testes (D) at E14.5 normalized to germ cell content by Mvh levels. Data represent mean ± SD; n = 3 embryos per group. *P < 0.05 (Student’s t test).