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. 2019 Apr 10;6(4):181877. doi: 10.1098/rsos.181877

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 9. — Histological observation and evaluation. (a) Distal femur morphology (a: the morphology of distal femur pre-implantation; b: the morphology of distal femur four weeks after implantation; c: the morphology of distal femur eight weeks after implantation; d: the morphology of distal femur 12 weeks after implantation). (b) The modified Mankin scores; the modified Mankin score in the PLGA group was significantly higher than that of the PLGA/icariin group at eight weeks and 12 weeks post-surgery (p < 0.05), *p < 0.05. (c) The chondrocytes were arranged in a straight line in the PLGA/icariin group, while the chondrocytes in the PLGA group were clustered, and the proteoglycan stained with toluidine blue was gradually reduced in both groups (e: HE stain of PLGA group; f: HE stain of PLGA/icariin group; g: toluidine blue stain of PLGA group; h: toluidine blue stain of PLGA/icariin group). Bar lengths are 200 µm.