Table 1.
Demographic and clinical characteristics of the participants
| All participants (n = 144) |
Participants w/CSF KYNA (n=100) |
|||||
|---|---|---|---|---|---|---|
| SN n=72 | HIV n=72 | p-valuea | SN n=51 | HIV n=49 | p-valuea | |
| Age (years) | 47.4 ± 1.7 | 50.3 ± 1.3 | 0.21 | 46.3 ± 2.04 | 50.8 ± 1.7 | 0.11 |
| Sex, # of males (%) | 63 (88 %) | 69 (96 %) | 0.07 | 45 (88 %) | 47 (96 %) | 0.27 |
| Education (years) | 14.5 ± 0.3 | 14.7 ± 0.3 | 0.30 | 14.6 ± 0.5 | 14.7 ± 0.4 | 0.44 |
| Index of social positionb (range: 14–77) | 40.4 ± 2.0 | 39.3 ± 2.0 | 0.52 | 41.2 ± 2.6 | 37.5 ± 2.3 | 0.17 |
| # with past diagnosis for depression (%) | 14 (19.5 %) | 30 (42 %) | 0.004 | 9 (18 %) | 19 (39 %) | 0.02 |
| # with past diagnosis for anxiety disorders (%) | 4 (6 %) | 14 (24 %) | 0.002 | 2 (4 %) | 11 (22 %) | 0.006 |
| # on current SSRI/SNRI treatments (%) | 8 (11 %) | 23 (32 %) | 0.002 | 6 (12 %) | 19 (39 %) | 0.002 |
| Race | ||||||
| American Indian/Alaska Native | 1(1 %) | 0(0 %) | 0.14 | 1(2 %) | 0(0 %) | 0.38 |
| Asian | 18(25 %) | 11(15 %) | 11(22 %) | 8(16 %) | ||
| Black or African American | 1(1 %) | 7(10 %) | 1(2 %) | 4(8 %) | ||
| More than one race | 9(13 %) | 11(15 %) | 4(8 %) | 8(16 %) | ||
| Native Hawaiian/Pacific Islander | 5(7 %) | 3(4 %) | 4(8 %) | 2(4 %) | ||
| White | 38(53 %) | 40(56 %) | 30(58 %) | 27(56 %) | ||
| # on HAART (%) | – | 63 (87.5 %) | – | – | 87.8 % | – |
| HIV duration (months) | – | 160.8 ± 11.3 | – | – | 154.2 ± 13.2 | – |
| CD4 (#/mm3) | – | 502.1 ± 29.2 | – | – | 481.7 ± 34.3 | – |
| Nadir CD4 (#/mm3) | – | 182.3 ± 17.1 | – | – | 181.7 ± 19.3 | – |
| # with detectable viral load (>75 copy/mL), % | – | 14 (19.4 %) | – | – | 11 (22.4 %) | – |
| Log viral load (log copy/mL) | – | 3.1 ± 0.24 | – | – | 3.0 ± 0.25 | – |
| CSF protein (mg/dL) | 41.9 ± 2.0 | 45.9 ± 2.1 | 0.14 | 40.5 ± 1.9 | 45.8 ± 2.5 | 0.17 |
| CSF glucose (mg/dL) | 62.0 ± 0.7 | 64.8 ± 1.5 | 0.44 | 62.8 ± 0.8 | 64.9 ± 1.8 | 0.73 |
| # KATII rs1480544 C-carrier (%)c | 65 (90 %) | 58 (81 %) | 0.14 | 45 (88 %) | 36 (74 %) | 0.09 |
| # KMO rs1053230 CC (%)c | 58 (80 %) | 52 (72 %) | 0.30 | 42 (82 %) | 32 (65 %) | 0.07 |
Presented are means and standard errors of demographic data for participants overall, and for the sub-cohort of participants with CSF-[KYNA] measurements
a
Mann-Whitney, ChiSq, or Fisher’s exact p value
b
Higher scores indicate lower social position
c
Distribution of the alleles in the entire cohort fulfilled the criteria for Hardy-Weinberg equilibrium for KATII SNP rs1480544 (p = 0.95), and the KMO SNP rs1053230 (p=0.08)