Table 3.
HIV serostatus and KATII or KMO genotypes on psychopathological symptoms
| Multivariate general linear model, p-values[F-value, df] | ||||||
|---|---|---|---|---|---|---|
| HIV | KMO | KATII | HIV × KMO | HIV × KATII | KMO × KATII | |
| Raw score (0–60) | ||||||
| CES-D | 0.07 [3.18,1] | 0.38 [0.76, 1] | 0.69 [0.16, 1] | 0.83 [0.05, 1] | 0.75 [0.10, 1] | 0.19 [1.66, 1] |
| SCL-90-R®, dimensional subscale T-scores | ||||||
| DEP | 0.36 [0.85, 1] | 0.81 [0.06, 1] | 0.52 [0.42, 1] | 0.27 [1.23, 1] | 0.23 [1.48, 1] | 0.44 [0.61, 1] |
| PAR | 0.27 [1.23, 1] | 0.28 [1.19, 1] | 0.74 [0.11, 1] | 0.27 [1.22, 1] | 0.09 [2.98, 1] | 0.66 [0.19, 1] |
| SOM | 0.25 [1.33, 1] | 0.97 [0.00, 1] | 0.45 [0.58, 1] | 0.87 [0.03, 1] | 0.34 [0.92, 1] | 0.26 [1.26, 1] |
| O-C | 0.53 [0.40, 1] | 0.81 [0.06, 1] | 0.94 [0.00, 1] | 0.78 [0.08, 1] | 0.04 [4.37,1] | 0.27 [1.22, 1] |
| HOS | 0.23 [1.47, 1] | 0.31 [1.05, 1] | 0.12 [2.47, 1] | 0.96 [0.00, 1] | 0.15 [2.10, 1] | 0.28 [1.18, 1] |
| I-S | 0.45 [0.58, 1] | 0.37 [0.80, 1] | 0.25 [1.31, 1] | 0.39 [0.74, 1] | 0.02 [5.29, 1] | 0.68 [0.17, 1] |
| PHB | 0.15 [3.50, 1] | 0.63 [0.24, 1] | 0.83 [0.05, 1] | 0.55 [0.37, 1] | 0.87 [0.03, 1] | 0.66 [0.20, 1] |
| ANX | 0.09 [2.94, 1] | 0.25 [1.35, 1] | 0.06 [3.62, 1] | 0.51 [0.43, 1] | 0.02 [4.86, 1] | 0.88 [0.02, 1] |
| PSY | 0.40 [0.72, 1] | 0.99 [0.00, 1] | 0.21 [1.59, 11] | 0.75 [0.10, 1] | 0.13 [2.28, 1] | 0.70 [0.14, 1] |
| SCL-90-R®, summary scale T-scores | ||||||
| PSDI | 0.33 [0.97, 1] | 0.93 [0.01, 1] | 0.68 [0.17, 1] | 0.22 [0.64, 1] | 0.33 [0.97, 1] | 0.67 [0.18, 1] |
| PST | 0.18 [1.84, 1] | 0.67 [0.18, 1] | 0.30 [1.08, 1] | 0.14 [0.70, 1] | 0.09 [2.99, 1] | 0.63 [0.23, 1] |
| GSI | 0.11 [2.52, 1] | 0.74 [0.11, 1] | 0.38 [0.77, 1] | 0.87 [0.03, 1] | 0.09 [2.77, 1] | 0.40 [0.70, 1] |
Presented are Multivariate General Linear Model p-, F-values, and degree of freedom ([F-value, df]) with the psychopathological symptoms scores for the Center for Epidemiologic Studies Depression scale (CES-D) and Symptom Checklist-90-R (SCL-90-R®) scores as dependent variables, and HIV serostatus, KATII or KMO genotypes as explanatory variable while adjusting for age and SSRI/SNRI treatment as a categorical term. p-values in bold font indicate significance or trends for significance
Symptom Checklist 90-R (SCL-90-R) T-scores: DEP depression, PAR paranoid ideation, SOM somatization, O-C obsessive-compulsiveness, HOS hostility, I-S interpersonal sensitivity, PHB phobic anxiety, ANX anxiety, PSY psychoticism, PSDI positive symptom distress index, PST positive symptom total, GSI global severity index