Table 2.
Univariate predictors of PsP
| PsP (N = 31) | No PsP (N = 52) | P-value | ||
|---|---|---|---|---|
| Age at RT | Median, y | 10.9 | 9.5 | P = 0.35 |
| Range, y | 3.9–17.0 | 1.0–17.6 | ||
| N (%) | N (%) | |||
| Sex | Male | 19 (61) | 27 (52) | P = 0.63 |
| Female | 12 (39) | 25 (48) | ||
| Histology | PA | 14 (45) | 36 (69) | P = 0.037 |
| Other LGG | 17 (55) | 16 (31) | ||
| WHO histologic grade | Grade I | 21 (68) | 41 (79) | P = 0.23 |
| Grade II | 10 (32) | 11 (21) | ||
| Tumor location | Brainstem | 7 (23) | 12 (23) | P = 0.55 |
| Cerebral hemispheres | 2 (6) | 4 (8) | ||
| Thalamus | 5 (16) | 8 (15) | ||
| Optic pathway/hypothalamus | 8 (26) | 21 (40) | ||
| Other | 9 (29) | 7 (13) | ||
| Tumor lateralization | Midline | 22 (71) | 32 (62) | P = 0.63 |
| Lateralized | 9 (29) | 20 (38) | ||
| Surgery prior to RT | GTR | 2 (6) | 2 (4) | P = 0.68 |
| STR | 12 (39) | 25 (48) | ||
| Bx | 17 (55) | 25 (48) | ||
| ChT prior to RT | No | 23 (74) | 28 (54) | P = 0.11 |
| Yes | 8 (26) | 24 (46) | ||
| RT dose | Median (Gy[RBE]) | 50.4 | 50.4 | |
| Range (Gy[RBE]) | 48.6–54 | 45–59.4 | ||
| N (%) | N (%) | |||
| RT dose | ≤50.4 Gy(RBE) | 22 (71) | 48 (92) | P = 0.016 |
| >50.4 Gy(RBE) | 9 (29) | 4 (8) | ||
| RT modality | IMRT | 8 (26) | 24 (46) | P = 0.048 |
| PBT | 23 (74) | 28 (54) | ||
| CTV | Median (cc) | 49.6 | 53.4 | P = 0.24 |
| Range (cc) | 7.6 - 200.8 | 4.5 - 429.2 |
Univariate analyses of predictors of PsP; P-values provided for univariate tests.Abbreviations: Bx, biopsy; ChT, chemotherapy; cc, cubic centimeter.