Figure 3. Inducible cDDAH1 KO exacerbated TAC-induced cardiomyocyte hypertrophy and ventricular fibrosis.
cDDAH1 KO did not affect LV fibrosis under control conditions, but exacerbated TAC-induced LV fibrosis (A,B); cDDAH1 KO significantly exacerbated TAC-induced increase of cardiomyocte size (C,D) in male mice. *p<0.05 compared to before TAC; #p<0.05 compared KO mice to wild type mice.