Table 2.
Particle size distributions of phage powders spray dried before and after a 12-month storage at 20 °C/15% RH.
| Formulation | T = 0 month | T = 12 month | ||||||
|---|---|---|---|---|---|---|---|---|
| D10 (µm) | D50 (µm) | D90 (µm) | Span | D10 (µm) | D50 (µm) | D90 (µm) | Span | |
| PEV61 90%LT 10%LC | 0.75 ± 0.00 | 1.90 ± 0.00 | 3.86 ± 0.03 | 1.63 ± 0.02 | 0.69 ± 0.11 | 1.81 ± 0.02 | 3.74 ± 0.09 | 1.69 ± 0.06 |
| PEV20 80%LT 20%LC | 0.76 ± 0.01 | 1.96 ± 0.01 | 4.09 ± 0.28 | 1.70 ± 0.14 | 0.76 ± 0.02 | 1.83 ± 0.08 | 3.70 ± 0.13 | 1.61 ± 0.02 |
| PEV61 80%LT 20%LC | 0.75 ± 0.01 | 1.85 ± 0.05 | 3.83 ± 0.09 | 1.63 ± 0.01 | 0.79 ± 0.08 | 1.76 ± 0.10 | 3.45 ± 0.43 | 1.50 ± 0.21 |
| PEV1 70%LT 30%LC | 0.79 ± 0.00 | 1.80 ± 0.03 | 3.70 ± 0.05 | 1.58 ± 0.01 | 0.78 ± 0.02 | 1.86 ± 0.04 | 3.68 ± 0.06 | 1.56 ± 0.02 |
| PEV20 70%LT 30%LC | 0.68 ± 0.09 | 1.77 ± 0.07 | 3.70 ± 0.11 | 1.67 ± 0.07 | 0.84 ± 0.05 | 1.76 ± 0.20 | 3.51 ± 0.54 | 1.44 ± 0.19 |
| PEV61 70%LT 30%LC | 0.79 ± 0.01 | 1.90 ± 0.03 | 3.80 ± 0.05 | 1.85 ± 0.00 | 0.74 ± 0.03 | 1.77 ± 0.05 | 3.50 ± 0.07 | 1.60 ± 0.01 |
| PEV20 55%LT 45%LC | 0.84 ± 0.04 | 1.87 ± 0.03 | 3.76 ± 0.05 | 1.56 ± 0.04 | 0.86 ± 0.08 | 1.76 ± 0.18 | 3.25 ± 0.52 | 1.37 ± 0.17 |
| PEV61 55%LT 45%LC | 0.81 ± 0.09 | 2.05 ± 0.13 | 4.23 ± 0.12 | 1.67 ± 0.12 | 0.91 ± 0.11 | 2.11 ± 0.12 | 4.47 ± 0.56 | 1.67 ± 0.23 |
D50 represents a cumulative 50% point of diameter (D10 and D90 represents a cumulative 10% and 90% point of diameters, respectively). D50 values are in bold as they are also known as “average particle size”.