Table 4.
In vitro cell viability assay of A549, HEK293 and THP-1 cells after 24 h exposure to phage formulations at 10, 100 and 1000 mg/L.
| Formulation Name | A549 cell survival (%) |
HEK293 cell survival (%) |
THP-1 cell survival (%) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 mg/L | 100 mg/L | 1000 mg/L | 10 mg/L | 100 mg/L | 1000 mg/L | 10 mg/L | 100 mg/L | 1000 mg/L | |||
| PEV61 90%LT 10%LC | 96.3 ± 0.6 | 96.7 ± 0.7 | 96.6 ± 0.5 | 98.9 ± 0.6 | 98.8 ± 4.2 | 100.0 ± 2.1 | 96.3 ± 2.8 | 96.0 ± 1.3 | 97.1 ± 2.5 | ||
| PEV20 80%LT 20%LC | 95.4 ± 0.8 | 96.0 ± 1.2 | 98.4 ± 1.6 | 97.4 ± 1.4 | 96.5 ± 3.2 | 97.6 ± 6.5 | 96.5 ± 2.0 | 98.9 ± 2.2 | 98.0 ± 2.9 | ||
| PEV61 80%LT 20%LC | 94.7 ± 1.8 | 94.8 ± 3.2 | 98.0 ± 1.3 | 95.0 ± 0.6 | 94.2 ± 7.9 | 94.2 ± 1.1 | 97.7 ± 0.9 | 95.0 ± 0.8 | 98.8 ± 0.7 | ||
| PEV1 70%LT 30%LC | 96.9 ± 3.2 | 97.4 ± 1.3 | 98.0 ± 1.2 | 99.0 ± 3.0 | 96.0 ± 1.8 | 95.5 ± 0.4 | 99.0 ± 3.0 | 97.3 ± 2.0 | 96.0 ± 2.8 | ||
| PEV20 70%LT 30%LC | 95.5 ± 3.2 | 92.5 ± 3.9 | 97.0 ± 1.5 | 95.0 ± 5.5 | 92.1 ± 2.1 | 96.2 ± 7.6 | 97.4 ± 3.3 | 96.1 ± 7.1 | 95.5 ± 6.0 | ||
| PEV61 70%LT 30%LC | 96.1 ± 1.8 | 96.7 ± 0.3 | 96.9 ± 1.2 | 99.3 ± 2.3 | 95.1 ± 1.6 | 94.8 ± 1.0 | 97.1 ± 1.6 | 95.1 ± 1.6 | 96.8 ± 0.8 | ||
| PEV20 55%LT 45%LC | 97.9 ± 3.0 | 95.4 ± 2.4 | 98.0 ± 2.2 | 94.7 ± 5.5 | 94.7 ± 1.7 | 94.0 ± 2.0 | 97.5 ± 0.2 | 98.8 ± 2.4 | 94.5 ± 3.9 | ||
| PEV61 55%LT 45%LC | 96.5 ± 2.4 | 96.0 ± 1.4 | 96.9 ± 1.8 | 96.9 ± 2.4 | 96.8 ± 2.4 | 96.3 ± 1.3 | 95.8 ± 3.1 | 97.7 ± 2.1 | 99.0 ± 2.5 | ||