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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: Mol Pharm. 2019 Mar 26;16(5):1958–1970. doi: 10.1021/acs.molpharmaceut.8b01319

Figure 4.

Figure 4.

Effect of Feno-NP on retinal vascular leakage and retinal edema in STZ-induced diabetic rats. Retinal edema was evaluated by total retinal thickness using OCT 2 and 4 weeks after Feno-NP treatment, and retinal vascular leakage was measured by permeability assay 8 weeks after Feno-NP treatment. (A) Representative images of OCT; (B) Quantification of total retinal thickness (n=12/group) on OCT; (C) Quantification of permeability (n=12/group). TRT: total retinal thicknesses; RPE: retinal pigment epithelial layer; RNFL: retinal nerve fiber layer; ONH: optic nerve head. Mean ± SEM. Two-way ANOVA followed by Bonferroni post hoc test. ** P < 0.01, versus normal rats; *** P < 0.001, versus normal rats. ## P < 0.01, versus untreated diabetic rats. δδ P < 0.01, versus Blank-NP treated diabetic rats.