Fig. 2. Distribution of epistasis values among sequential mutations in TEM-1.
(a) Observed fitness versus predicted fitness for 8,302 double mutant alleles. Predicted fitness assumes no epistasis. (b) The distribution of epistasis values among 8,302 double mutant alleles. Bars are stacked to show total fractions. Significant epistasis values are indicated in red. Supplementary Data S2 tabulates all epistasis values.