Skip to main content
. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: J Struct Biol. 2019 Mar 14;206(2):193–203. doi: 10.1016/j.jsb.2019.03.003

Fig. 6. Open and closed conformations of the PAM structural model.

Fig. 6.

Dimeric models were drawn to scale in ChemDraw Professional 16.0 based upon the domain organization of PAMAP53. (A) At 4° C, the HVR with some α-helix content dimerizes and forms a closed pattern at the NH2-terminus. (B) At 25° C or 37° C, loss of α-helices within the HVR regions occur, eventually resulting in an open status of NH2-terminal domains, viz., HVR-A-B domains. The numbers of the first residue in each domain are listed on the illustration.