Table 4:
Multivariable model of in-hospital mortality
| Variable | Odds ratio (95% CI) | P-value |
|---|---|---|
| Indication for ECMO | <0.001 | |
| eCPR | 4.36 (2.23, 8.51) | |
| Cardiac | 2.42 (1.46, 4.02) | |
| Respiratory | Reference | |
| Age | 0.031 | |
| Pre-term neonate | 3.10 (1.52, 6.33) | |
| Full-term neonate | Reference | |
| Infant | 1.47 (0.87, 2.48) | |
| Child | 1.11 (0.60, 2.07) | |
| Adolescent | 1.44 (0.67, 3.07) | |
| Congenital diaphragmatic hernia | 3.11 (1.49, 6.49) | 0.002 |
| Meconium aspiration syndrome | 0.18 (0.05, 0.63) | 0.007 |
| Baseline pH in arterial blood | 0.22 (0.06, 0.80) | 0.022 |
| Partial thromboplastin time (increase of 10 seconds) | 1.07 (1.00, 1.14) | 0.048 |
| International normalized ratio | 1.45 (0.95, 2.23) | 0.085 |
| Documented blood infection prior to ECMO | 5.26 (1.90, 14.57) | 0.001 |
Estimated probability of mortality is p = ex/(1+ex), where x = 9.081 + 0.887[Indication = cardiac] + 1.468[Indication = eCPR] + 1.132[Age = pre-term neonate] + 0.378[Age = infant] + 0.109[Age = child] + 0.360[Age = adolescent] + 1.138[Congenital diaphragmatic hernia] - 1.710[Meconium aspiration syndrome] - 1.534[pH in arterial blood] + 0.0064[Partial thromboplastin time (seconds)] + 0.357[International normalized ratio] + 1.659[Documented blood infection] is the log odds of mortality from the multivariable model. Using leave-one-out cross validation to prevent small-sample bias, the area under the ROC curve is 0.75 (0.70, 0.80).