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. 2019 Mar 18;76(11):2077–2091. doi: 10.1007/s00018-019-03054-z

Fig. 2.

Fig. 2

Critical signaling pathways involved in osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells. Simplified schematic illustration of important phosphate-induced signaling pathways discussed in this review, ultimately leading to osteo-chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs), development of a pro-calcifying environment, and vascular calcification. For details and abbreviations, see the full text