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. 2019 Feb 15;76(11):2231–2243. doi: 10.1007/s00018-019-03041-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Ectopic expression of miRNA located at 14q32 reduced cell proliferation in multiple NB cell lines. a Heatmap representing effects of the indicated miRNA on cell proliferation reduction in MYCN amplified (MNA) and MYCN non-amplified (non-MNA) cell lines. The overexpression effect of each miRNA on cell proliferation was compared to mock-transfected cells. b, d Relative expression (log₂) of miR-342 (b) and miR-323a (d) in MNA and non-MNA NB tumors. c, e Overall survival Kaplan–Meier plot of the indicated miRNA expression in human NB tissues