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. 2019 Apr 1;76(11):2133–2169. doi: 10.1007/s00018-019-03068-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Regulation of AMPAR trafficking by PSD95 and TARP γ2/stargazin. PSD95 and TARP γ2/stargazin regulate AMPAR synaptic trapping. PSD95 anchors stargazin-bound freely diffusing AMPARs at the PSD, thereby enhancing synaptic strength. Stargazin phosphorylation in its cytoplasmic tail promotes PSD95 binding; upon dephosphorylation, stargazin-bound AMPARs are endocytosed or diffuse out of the synapse. Additional posttranslational modifications on PSD95 or stargazin modulate this binding in either direction. Stargazin also regulates AMPAR synaptic trafficking by interacting with MAP1A-LC2