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. 2019 Apr 1;76(11):2133–2169. doi: 10.1007/s00018-019-03068-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Regulation of AMPAR trafficking by TARP γ3, γ4, γ7, and γ8, CNIH and GSG1L. TARP γ3, γ4, γ7, and γ8, CNIH2 and 3, and GSG1L modulate AMPAR trafficking to and at the synapse. γ3, γ4, and γ8 and CNIH2 together, target AMPARs to the extrasynaptic pool. γ8 and CNIH2 also cooperatively regulate AMPAR lateral diffusion to and anchoring at the synapse, by binding MAGUK proteins. TARP γ7 and CNIH3 are also present at the synapse. GSG1L, on the other hand, promotes AMPAR endocytosis and negatively regulates AMPAR trafficking to the synapse