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. 2019 May 6;9:6978. doi: 10.1038/s41598-019-43295-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The relationship between nasal epithelial gene expressions associated with smoking-cessation and cessation-induced changes in cross-sectional bronchial epithelium gene expression Nasal epithelial genes whose expression decreased after smoking-cessation were concordantly enriched among bronchial epithelial genes whose expression levels were lower in long-term former smokers compared to current smokers (FDR < 10⁻³). The color bar indicates ranking of genes with response to gene expression changes when comparing current verses long term former smokers. Vertical bars indicate genes substantially decreased with smoking-cessation in the current study. The height of the bars indicates the running GSEA enrichment score.