Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 6;9:6978. doi: 10.1038/s41598-019-43295-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Genes that reverse with short-term smoking-cessation are enriched among genes that are induced with rapid kinetics with acute whole cigarette smoke exposure in vitro. Nasal epithelial genes whose expression are reversed with smoking-cessation were concordantly enriched among genes that whose expression are induced of NHBE to CS for 15 minutes invitro (FDR_GSEA < 0.02). The color bar (A) indicates the association of NHBE gene expression in response to cigarettes smokes exposure (red = increased gene expression after CS exposure; blue = decreased gene expression after CS smoke exposure). Vertical bars indicate genes associated with smoking-cessation. The height of the bars indicates the running GSEA enrichment score. Expression of the common leading edge genes between the two datasets (red block in a) is shown in both panels b and c. Leading edge genes that are rapidly reversible upon short-term smoking-cessation in in the nasal epithelium (B) are enriched among the genes that are induced following 15 minute in vitro exposure (C) of NHBE to smoke from either “Full flavor” or “Light” tobacco cigarettes over 24 hours. This data demonstrates that that gene-expression response to tobacco exposure occurs with rapid kinetics and these genes are rapidly reversible with short-term smoking-cessation.