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. 2019 May 6;9:6978. doi: 10.1038/s41598-019-43295-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kinetics of genes altered with smoking-cessation and functional categories. For each of the seven functional categories that are over represented among the 119 genes that change after smoking-cessation, we calculated a metagene score to summarize the behavior of the genes. The metagene score for the expression of genes in four of these functional categories substantially associated with time since smoking-cessation are shown here. Of the functional categories, genes involved in xenobiotic metabolism were altered within four weeks of smoking-cessation, while the other categories changed more gradually.