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. 2019 May 6;10:2074. doi: 10.1038/s41467-019-10078-3

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© The Author(s) 2019

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Fig. 3 — Binding of the FAD cofactor. Anionic/polar residues responsible for the negative electrostatic potential are indicated. Several hydrophobic side chains around the isoalloxazine preferably stabilize the uncharged FAD and FADH• states