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. 2019 May 6;9:6956. doi: 10.1038/s41598-019-43355-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-130b promoted invasion by targeting TIMP-2 in A549 cells. Control (mock) or miR-130b-overexpressing A549 cells (130b) were transfected with the control vector (empty) or TIMP-2 expression vector (TIMP-2) for 48 h. Cells were then subjected to western blot analysis (A), invasion assays (B), and gelatine-zymography (C). Uncropped Western blot and zymography data are shown in Supplementary Fig. 10. Representative results from three independent experiments are shown. The numbers indicate the relative expression of TIMP-2 compared to that of control (mock/empty) A549 cells, as analyzed by densitometry (A,C). Data are the means ± standard deviations of three independent experiments in A, B, and C. *p < 0.05 for one-way analysis of variance followed by post-hoc Bonferroni multiple comparison tests.