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. 2019 May 6;9:6934. doi: 10.1038/s41598-019-43459-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistochemical characterization of representative rabbit liver samples after gene transfer with lentiviral vectors. Representative images of HE-stained liver 1 year after LV-LDLR (a) and LV-control (d) gene transfers. (b,e) Immunohistochemical staining with a pan-cytokeratin antibody stained large and small bile ducts in the liver in both groups. (c,f) Individual Ki-67 positive cells were seen in bile ducts of LV transduced animals one year after gene transfer. No significant difference was seen between the treatment groups. Magnification 200x, inserts 400x. Scale bar: 100 µm.