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. 2019 May 6;9:6922. doi: 10.1038/s41598-019-43364-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-37 is increased in the brain after stroke in a human and in IL-37tg mice, and is associated with a lower median clinical score in mice. Photomicrographs showing IL-37 immunoreactivity is (a) absent in a brain section from the contralateral hemisphere and (b) present (arrows) in the ischemic hemisphere of a stroke patient. Scale bar = 100 µm. (c) Expression of IL-37 mRNA in brains of IL-37tg mice 24 h after sham surgery (n = 8) or in the ischemic hemisphere after stroke (n = 13). The mean of the sham group is set as 1.0. **P < 0.01; Welch’s t-test. (d) Clinical score for wild-type (WT; n = 12) and IL-37tg mice (n = 13) at 24 h after stroke (P = 0.747; Mann-Whitney test). Data in (c,d) are presented as mean ± S.E.M. or median, respectively.