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. 2019 Apr 30;6:26. doi: 10.3389/fmolb.2019.00026

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Copyright © 2019 Judge, Wu, Tayyari, Hattori, Glushka, Ito, Arnold and Edison.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integration of central metabolic pathways. Arrows correspond to one or more reactions, and nodes correspond to metabolites (Dreyfuss et al., 2013; Kanehisa et al., 2016). Nodes are filled for observed metabolites. Plots show the means of scaled peak/ridge intensities for a given compound in a given replicate over traceable times, where red and blue trajectories represent aerobic and anaerobic conditions, respectively. Arrows indicate typical reaction directions. The glyoxylate cycle is shown as a shunt through glyoxylate embedded in the TCA cycle.