TABLE 1.

Proteins regulated by USP7.

USP7 substrates	Processes	Related cancer	References
EBNA1	Viral proteins		Holowaty et al.,2003
ICP0			Pfoh et al.,2015
vIRFs			Chavoshi et al., 2016; Xiang et al.,2018
LANA			Jager et al.,2012
E1B-55K			Ching et al.,2013
Tat			Ali et al.,2017
Foxp3	Immune response	Non-small cell lung cancer	van Loosdregt et al., 2013; Wang L. et al.,2016
TRIM27		Cervical carcinoma	Cai et al.,2018
NLRP3		Leukemia	Palazon-Riquelme et al.,2018
C-Myc and N-Myc	Oncoproteins	Neuroblastoma	Bhattacharya and Ghosh,2015
p53	Tumor suppressor proteins	Ovarian cancers	Oliner et al., 1992; Li et al.,2002
DAXX		Breast cancer	Tang et al.,2006
PTEN		Chronic lymphocytic leukemia	Morotti et al.,2014
FOXOs family		Lung carcinoma	Huang et al.,2005
DNMT1	Epigenetics	Colon cancer	Du et al., 2010; Bronner,2011
SUMO			Lecona et al.,2016
LSD1		Medulloblastoma	Yi et al.,2016
CHK1	DNA damage and repair		Alonso-de Vega et al.,2014
UVSSA			Sarasin, 2012; Zhang et al.,2012
ANXA1		Hela	Park et al.,2015
XPC			He et al.,2014
HLTF, Rad18			Qing et al.,2011
Polη			Qian et al.,2015
RNF168		Breast cancer	Malapelle et al.,2017
PHF8		Breast cancer	Wang Q. et al.,2016
MDC1		Cervical cancer	Su et al.,2018
Wnt/β-catenin signaling pathway	Several canonical signaling pathways	Colorectal cancer	Novellasdemunt et al.,2017
NF-κB signaling pathway		Multiple myeloma	Colleran et al.,2013
NOTCH signaling pathway		Lymphoblastic leukemia	Shan et al.,2018