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. 2019 Apr 30;10:403. doi: 10.3389/fphar.2019.00403

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Copyright © 2019 Tong, Qi, Yang, Li, Wang, Lan, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PASE on target organ hypertrophy and fibrosis. Histology of thoracic aortal and left ventricular tissues from SHR after 12-week administration of PASE. H&E staining (A) were used to investigate the morphological changes and Masson staining (B) to examine fibrosis levels in the target organs (original magnification × 200). Contents of collagen in thoracic aorta (C), myocardial interstitial (D), and perivascular spaces (E) of left ventricle were also measured. Data are presented by means ± SE; n = 6 per group. Statistical analyses were performed by one-way ANOVA with Bonferroni post hoc test. Labeled means without a common letter indicated a significant difference at p < 0.05 (a > b) between groups.