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Neither crocin nor its metabolite, crocetin, could enter the brain in the normal and cerebral I/R rats. (A) Oral administration of crocin (60 mg/kg). (B) Intravenous administration of crocin (1 mg/kg). Data are expressed as the mean ± SD (n = 5). N.D., under the lower limit of detectability (2 ng/mL).
