FIGURE 4.

The effect of crocetin on cerebral I/R injury. Crocetin was treated at equal molar dose to crocin (0.33 mg/kg for intravenous administration and 20 mg/kg for oral administration). Representative images of the same brain stained with TTC (A), average infarction volumes corrected for brain edema as indicated (B) and the neurological deficit scores in each group (C) are shown after the intravenous administration of crocetin. Data are represented as the mean ± SD (n = 6), N.D., infarction not detected. Representative images of the same brain stained with TTC (D), average infarction volumes corrected for brain edema as indicated (E) and neurological deficit scores for each group (F) are shown after the oral administration of crocetin. Data are presented as the mean ± SD (n = 6), N.D., infarction not detected. ^∗∗P < 0.01 vs. model group.