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. 2019 Apr 30;10:440. doi: 10.3389/fphar.2019.00440

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Copyright © 2019 Zhang, Geng, Hong, Jiao, Li, Sun, Xie, Yan, Aa and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cross-interaction between gut microbiota and crocin was abolished in pGF rats. (A) PK curves of crocin and crocetin after oral administration (crocin, 58.6 mg/kg; crocetin, 19.7 mg/kg) (mean ± SD, n = 6); (B) PLS-DA scores plots of gut content collected 6 h after crocin or vehicle administration. (C) The metabolites identified to be significantly different between crocin administered and control rats, (mean ± SD, n = 6). ^∗P < 0.05, ^∗∗P < 0.01 vs. control group.