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. 2019 Apr 30;13:18. doi: 10.3389/fnbeh.2019.00018

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Copyright © 2019 Piggott, Bosse, Lisieski, Strader, Stanley, Conti, Ghoddoussi and Perrine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SPS on neural activity in multiple brain regions assessed with manganese (Mn²⁺)-enhanced MRI (MEMRI). Magnetization prepared rapid acquisition gradient echo/proton density weighted (MPRAGE/PDGE) images of coronal sections containing (A) the prelimbic (PL) and infralimbic (IL) cortices, (B) the basolateral (BLA) and central extended (CeA) amygdala, and (C) the dorsomedial (dmSTR) and dorsolateral (dlSTR) striatum. Each panel (A–C) from left to right shows: region of interest (ROI) placements on a representative MPRAGE/PDGE ratio image (pseudocolor indicates signal intensity, scale bar: lighter color indicates higher activity with arbitrary units and Mn²⁺ uptake) adjacent to the corresponding rat brain atlas image (adapted from Paxinos and Watson, 2007), and average normalized signal intensities plotted as % prescan (mean ± SEM) for each ROI (control n = 8, SPS n = 9). *p < 0.05 compared to controls.