Figure 1.

(A) Mediators of MDSC expansion and activation in a mycobacterial environment. A schematic depicting mediators associated with the proposed “two-signal” MDSC expansion and activation process, in a mycobacterial environment. These include cytokines, chemokines, calcium-binding proteins, and matrix metalloproteinases. (B) MDSC cellular interaction and mediators of immunosuppression in a mycobacterial environment. Examples of the known and suggested interactions of MDSC with other immune cells in the mycobacterial setting, including the soluble mediators associated with their immunosuppressive activity.