Figure 2.

HDAC4 mutations impair β‐cell function. a. Insulin secretion in mouse SJ β‐cells was suppressed by transfection with three mutated HDAC4 at both low (3.3 mmol/L) and high glucose levels (16.7 mmol/L) compared to that in the cells transfected with wild‐type HDAC4. Technical replications =4, biological replications =4. b. Pancreatic β‐cell‐specific transcriptional and regulatory factors were down‐regulated by the mutated HDAC4. Statistical analyses were performed using GraphPad Prism 5.0 software. *: p < 0.05, **:p < 0.01, ***: p < 0.001, ns: not significant