Table 4.
d‐glucose | d‐galactose | ||
---|---|---|---|
Tissue | K i ± SEM (μmol/L) | Tissue | K i ± SEM (μmol/L) |
Jejunum | nd | Jejunum | 4.6 ± 0.9A |
Ileum | 6.0 ± 1.0 | Ileum | 1.8 ± 0.6B |
Distal colon | nd | Distal colon | nd |
K i (μmol/L) values represent dapagliflozin inhibition of sodium‐dependent electrogenic d‐glucose (jejunum: N = 12, Ileum: N = 12, distal colon: N = 11) and d‐galactose (all tissues: N = 6) absorption for each tissue type in pig. ND represents nondetectable inhibition. Data are presented as means ± SEM. Significant differences represented by different letter superscripts between K i values for jejunum and ileum inhibition of d‐galactose transport (Student's t‐test, P < 0.05).