Table 3.

Pearson's correlations between annual rate of brain aging and relevant clinical and MRI variables on time point 3.

	Fullbrain		Frontal		Parietal		Cereb. / Subcort.
Clinical variables	cor.	p	cor.	p	cor.	p	cor.	p
EDSS	0.09	0.49	−0.01	0.95	−0.15	0.25	0.22	0.08
Change in EDSS	0.16	0.23	0.09	0.50	−0.03	0.83	0.29	0.026
MSSS	−0.03	0.84	−0.09	0.47	−0.21	0.11	0.17	0.20
Change in MSSS	0.17	0.21	0.10	0.46	0.05	0.68	0.36	5.1 × 10−3
9HPT Non-dominant	0.29	0.028	0.15	0.27	0.01	0.92	0.30	0.021
Change in 9HPT Non-dominant	0.31	0.017	0.20	0.14	0.08	0.53	0.32	0.014
DMT Level	−0.28	0.031	−0.22	0.09	−0.17	0.21	−0.08	0.54
MRI variables	cor.	p	cor.	p	cor.	p	cor.	p
WMLL	0.29	0.026	0.21	0.11	0.19	0.16	0.01	0.96
Change in WMLL	0.30	0.015	0.19	0.12	0.35	4.3×10−3	0.00	0.98
Brain volume	−0.01	0.93	−0.08	0.54	−0.03	0.83	0.10	0.44
Brain atrophy	−0.79	4.3×10−15	−0.79	1.6×10−15	−0.72	1.1×10−11	−0.07	0.57

Significant associations are highlighted with bold (p < 0.05). Associations which were still significant after adjusting for false discovery rate are underlined. Cereb., cerebellar; Subcort., subcortical; Cor., correlation; EDSS, expanded disability status scale; MSSS, multiple sclerosis severity score; 9HPT, nine hole peg test; DMT, disease-modifying therapies; WMLL, white matter lesion load.