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. 2019 Apr 30;12:105. doi: 10.3389/fnmol.2019.00105

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Copyright © 2019 Xu, Li, Gao, Lenahan, Zheng, Yan, Shao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transmission electron microscopy images of the morphometric changes of brain tissues. (A) Sham; (B) ICH + vehicle; (C) ICH + NaB (scar bar = 2 μm); (D–F) Magnification of (A–C) (scar bar = 0.5 μm); (G) The quantification of mitochondrial vacuolation rate. ^∗p < 0.05 vs. sham, ^#p < 0.05 vs. ICH + vehicle at 24 h, n = 3 per group. Mitochondria (black arrows) with prominent cristae and an intact membrane and nucleus (asterisk) with a clear membrane and homogenous chromatin was observed in sham group. The induction of ICH results in irregular mitochondria with damaged cristae and condensed chromatin. However, NaB administration notably reversed the results.