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VEH/SIV rhesus macaques have significantly high amounts of collagen deposition in lymph node paracortex and B-cell follicles (A–D) (red arrows) compared to THC/SIV rhesus macaques (E–G). Note blue staining collagen (red arrow) (Gomori one-step trichrome stain) in (A–D). Image quantification confirmed high collagen deposition in lymph nodes of VEH/SIV rhesus macaques (H).
