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. 2019 Apr 30;10:287. doi: 10.3389/fpsyt.2019.00287

Figure 5.

Figure 5

The effects of CUMS and ketamine on Tau protein in the synapses of the hippocampus of C57BL/6 mice. (A) Total Tau and hyperphosphorylated Tau protein in the synapses of the hippocampus. (B, C, and F) After CUMS, the levels of pSer396, pSer404, and total Tau protein increased; ketamine decreased the levels of hyperphosphorylation at pSer396 and pSer404 sites in the synapses, but not total Tau. (D and E) Levels of pSer199 and AT8 did not change after CUMS and ketamine treatment did not alter the levels in the synapses. Data are expressed as mean ± SD; n = 10 per group. One-way ANOVA was used to compare differences among the groups (*p < 0.05, **p < 0.01).