Skip to main content
. 2019 Apr 30;10:287. doi: 10.3389/fpsyt.2019.00287

Figure 6.

Figure 6

CUMS decreased the levels GluA1 and PSD95 of hippocampus synapses in C57BL/6 mice, with a rapid reversal by ketamine. CUMS did not decrease the levels of GluA1 and PSD95 of hippocampus synapses of Tau KO mice, and ketamine had no effect on the Tau KO mice. (A) Representative Western blot images of the GluA1 and PSD95 of C57BL/6 mice are shown. (B and C) CUMS decreased the expression of GluA1 and PSD95, and this deficit was reversed by a single dose of ketamine. (D) Representative Western blot images of GluA1 and PSD95 of Tau KO mice are shown. (E and F) CUMS and ketamine did not change the levels of GluA1 and PSD95 of Tau KO mice. Results were quantified and expressed as the mean ± SD percent of the control; n = 10 (*p < 0.05, **p < 0.01).