Table 3.
Antimicrobial activity of individual fractions of AMPs and antibiotics against drug-resistant clinical isolates.
| MICa (μM) against drug-resistant clinical isolates | |||||
|---|---|---|---|---|---|
| Gram-negative | Gram-positive | ||||
| Sample | E. coli ESBL 521/17 | A. baumannii 7226/16 | P. aeruginosa MDR 522/17 | K. pneumoniae ESBL 344/17 | S. aureus 1399/17 |
| PG-1 | 0.4 | 6.25 | 1.6 | 1.6 | 1.0 |
| ChBac3.4 | 6.25 | 12.5 | 6.25 | 6.25 | 12.5 |
| Oxacillin | >50 [100] | >50 [100] | >50 [100] | >50 [100] | >50 [100] |
| Meropenem | 0.04 | >50 [100] | 25 | 0.04 | 6.25 |
| Erythromycin | >50 [100] | >50 [100] | >50 [100] | 50 | >50 [100] |
| Amikacin | 1.0 | 6.25 | 1.0 | 0.25 | >50 [100] |
| Ofloxacin | 50 | 25 | >50 [100] | 0.25 | >50 [100] |
a
Minimal inhibitory concentrations (MIC) values are medians of 3–6 independent experiments made in triplicates. If actual MIC value was out of the tested concentrations range, it was assessed as twice the maximal tested concentration; the corresponding value is given in square brackets.