Table 5.
Antimicrobial activity of colloidal silver preparation “Poviargolum” alone and in combinations with PG-1 or ChBac3.4 against drug-resistant clinical isolates.
| Bacteria | Poviargolum MICa (μg/ml) | Poviargolum and PG-1 FICIb | Poviargolum and ChBac3.4 FICIb |
|---|---|---|---|
| E. coli ESBL 521/17 | 78 | 0.56 | 0.375 |
| A. baumannii 7226/16 | 78 | 0.5 | 0.75 |
| P. aeruginosa MDR 522/17 | 78 | 0.5 | 0.625 |
| K. pneumoniae ESBL 344/17 | 78 | 0.5 | 0.5 |
| S. aureus 1399/17 | 156 | 0.62 | 0.5 |
a
Minimal inhibitory concentrations (MIC) values are medians of 4 independent experiments made in triplicates.
b
Fractional Inhibitory Concentration Indices (FICI) values are medians of 3–4 independent experiments; FICI > 2 indicates antagonism, 1 < FICI ≤ 2 shows independent action, 0.5 < FICI ≤ 1 corresponds to additivity, FICI ≤ 0.5 denotes synergy; synergy cases are set off in bold type.