Table 4.

Univariate analysis.

Variable		5 y LRFS		5y DMFS		5y DSS		5y OS
		%	p	%	p	%	p	%	p
Age	< 65	61.3	0.598	82.2	0.348	73.7	0.166	67.5	0.030
	≥ 65	68.7		86.0		63.8		50.9
Gender	Male	71.4	0.025	83.1	0.909	69.4	0.897	58.7	0.465
	Female	36		84.4		69.3		65.4
Subsite	Tongue- oral floor	66.6	0.656	84.6	0.374	73.4	0.266	63.5	0.300
	TRM- Alveolar crest	54.2		76.2		53		47.4
	Other	67.5		100		85.7		85.7
pT	T1-T2	74.1	0.006	92.1	0.002	79	0.004	70.6	0.003
	T3-T4	37		74.5		59		50.6
pN/ENE	N0	82.4	< 0.0001	93.7	< 0.0001	77.4	< 0.0001	78	< 0.0001
	N+/ENE-	26.3		83		63		57.3
	N+/ENE+	0		57.5		35.2		27.8
Stage	I-II	88.4	< 0.0001	95.9	0.001	92.2	< 0.0001	83.5	0.0001
	III-IV	51		76.8		57.4		49.3
Surgical margins	Negative	66.6	0.455	86.3	0.054	72.4	0.192	65.3	0.063
	Positive	53.4		70.7		53.5		41.8
Grading	G1	87.2	0.030	88.9	0.335	80.9	0.308	67.5	0.266
	G2	66.9		77.8		68		58.5
	G3	37.5		88.7		66.4		61.8
Perineural spread	Absent	73.4	0.013	92	0.0006	80.1	0.004	68.6	0.079
	Present	43.8		74.6		58		53.3
Lymphovascular invasion	Absent	64.4	0.216	89.7	0.001	75.6	0.0008	68.6	0.001
	Present	66.9		66.1		48.3		38.2
Bone invasion	Absent	71.1	0.003	84.1	0.465	73.2	0.057	63.5	0.161
	Cortical	62.9		92.9		78.8		65.7
	Medullary	0		72.6		39.1		39.1
*Nodal ratio	< 0.07	56.3	0.206	70.24	< 0.0001	58.1	0.023	49.4	0.066
	≥ 0.07	39.5		0		29.3		26.9
	< 0.1	56.2	0.040	67.7	< 0.0001	57.7	0.002	49.5	0.009
	≥ 0.1	31.2		0		12.8		11.9
*Number of positive nodes	1-2	52.4	0.223	#86.4	0.007	61.8	0.001	55.8	0.001
	3-4	53.4		#63.9		42.1		33.7
	≥ 5	38.8		#59.3		13.7		11.8

ENE, extranodal extension; N+, node metastasis; RMT, retromolar trigone;

^*Analysis performed in the subgroup of patients with nodal metastasis (n = 85); # Survival at 2 years.

Bold indicates p values inferior to 0.05 (statistical significant).