Table 5.
Multivariate analysis.
| LRFS | DMFS | DSS | OS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | ||
| pT (T3-T4 vs. T1-T2) | 1.56 (0.83–2.92) | 0.169 | 2.64 (1.06–6.56) | 0.037 | 1.6 (0.83–3.07) | 0.162 | 1.53 (0.89–2.62) | 0.126 | |
| pN/ENE | pN0 | 1 | 1 | 1 | 1 | ||||
| pN+ ENE- | 3.95 (1.92–8.12) | < 0.001 | 1.77 (0.6–5.23) | 0.302 | 2.64 (1.19–5.83) | 0.017 | 1.76 (0.94–3.3) | 0.080 | |
| ENE+ | 4.08 (1.96–8.48) | < 0.001 | 6.82 (2.62–17.75) | < 0.001 | 5.97 (2.84–12.54) | < 0.001 | 3.83 (2.12–6.94) | < 0.001 | |
| Perineural invasion | 1.26 (0.71–2.24) | 0.426 | 4.39 (1.76–10.95) | 0.002 | 2.02 (1.09–3.73) | 0.025 | 1.47 (0.89–2.41) | 0.129 | |
| NLR* | – | 0.005 | – | 0.046 | – | 0.078 | – | 0.176 | |
ENE, extranodal extension; HR, hazard ratio; CI, confidence interval; N+, node metastasis.
*
Neutrophil to lymphocyte ratio (NLR) was modeled using a restricted cubic spline with 3 knots placed at 10, 50, and 90% quantiles. Bold indicates p values inferior to 0.05 (statistical significant).