Table 2.
List of main physiological parameters involved in the modelling. For each of them the role in the estimation process (“measured”, “estimated”, “calculated” or assumed “fixed”) and relative value (prior: [mean, standard deviation], fixed value or defining equation) and units are reported.
| Parameter | Role in modelling | Value | Units |
|---|---|---|---|
| OEF | estimated | prior: [0.35,0.1] | – |
| CBF | estimated | prior: [60,Inf] | ml/100 g/min |
| CVR | estimated | prior: [3, 0.774] | %/mmHg |
| K | estimated | prior: [0.07, 0.087] | – |
| CMRO2 | calculated | (Eq. A-11) | μmol/100 g/min |
| PaCO2 | measured | – | mmHg |
| PaO2 | measured | – | mmHg |
| M0,blood | measured | – | – |
| θ | fixed | 0.06 | – |
| φ | fixed | 1.34 | ml/g |
| Hb | fixed | 15 | g/dl |
| T1b | calculated | (Eq. A-9) | s |
| b; c (Eq. A-9) | fixed | -5x10−4; 1.78 | s/mmHg; s |
| tmax(Eq. A-10) | fixed | 0.2 | s |