Table 3.
Descriptive data of hospital contacts of potential painful and non-painful DPN and potential diabetic foot ulcer identified using ICD-10 hospital codes and/or surgery in the DNPR and prescription codes in the NHSPD from 2009 to 2016
| Painful DPN, N=53 |
Non-painful DPN, N=54 |
Diabetic foot ulcer, N=53 | |
|---|---|---|---|
| Sex | |||
| Male | 34 (64) | 40 (74) | 34 (64) |
| Female | 19 (36) | 14 (26) | 19 (36) |
| Age, years | |||
| Median (quartiles) | 64 (53–69) | 67 (61–74) | 74 (62–83) |
| Hospital type | |||
| University hospital | 22 (42) | 20 (37) | 19 (36) |
| Regional hospital | 31 (58) | 34 (63) | 34 (64) |
| Department type | |||
| Internal medicine | 13 (25) | 12 (22) | 12 (23) |
| Neurological | 9 (17) | 15 (28) | 1 (2) |
| Neurophysiological | 22 (42) | 18 (33) | 0 (0) |
| Orthopaedic surgery | 5 (9) | 5 (9) | 21 (40) |
| Vascular surgery | 5 (8) | 4 (7) | 14 (26) |
| Dermatological | 0 (0) | 0 (0) | 4 (8) |
| Plastic surgery | 0 (0) | 0 (0) | 1 (2) |
| Admission type | |||
| Inpatient | 9 (17) | 13 (24) | 16 (30) |
| Outpatient | 44 (83) | 41 (76) | 37 (70) |
| Diabetic foot ulcer code type | |||
| Diagnosis code, only | N/A | N/A | 26 (49) |
| Surgery code, only | N/A | N/A | 18 (34) |
| Diagnosis+surgery code | N/A | N/A | 9 (17) |
| Diagnosis code typea | |||
| Primary diagnosis code | 38 (72) | 28 (52) | 16 (30) |
| Secondary diagnosis code | 16 (30) | 26 (48) | 19 (36) |
| Polyneuropathy – diagnosis codeb | |||
| E10.4-E14.4 (diabetes with neurological complication) | 19 (36) | 30 (56) | N/A |
| E10.4 | 2 (4) | 8 (15) | N/A |
| E11.4 | 11 (21) | 15 (28) | N/A |
| E12.4 | 0 (0) | 0 (0) | N/A |
| E13.4 | 2 (4) | 2 (4) | N/A |
| E14.4 | 4 (8) | 5 (9) | N/A |
| DG62.9 (polyneuropathy, unspecified) | 24 (45) | 19 (35) | N/A |
| DG63.2 (diabetic polyneuropathy) | 11 (21) | 5 (9) | N/A |
| Type of neuropathic analgesicsc | |||
| Antiepileptic medicine | |||
| Gabapentin | 21 (40) | 0 (0) | N/A |
| Pregabalin | 14 (26) | 0 (0) | N/A |
| Lamotrigine | 2 (4) | 0 (0) | N/A |
| Valproic acid | 1 (2) | 0 (0) | N/A |
| Carbamazepine | 2 (4) | 0 (0) | N/A |
| Oxcarbazepine | 0 (0) | 0 (0) | N/A |
| Serotonin–noradrenalin reuptake inhibitors | |||
| Venlafaxine | 1 (2) | 0 (0) | N/A |
| Duloxetine | 0 (0) | 0 (0) | N/A |
| Tricyclic antidepressants | 0 (0) | N/A | |
| Imipramine | 2 (4) | 0 (0) | N/A |
| Clomipramine | 0 (0) | 0 (0) | N/A |
| Amitriptyline | 23 (43) | 0 (0) | N/A |
| Nortriptyline | 6 (11) | 0 (0) | N/A |
| Maprotiline | 1 (2) | 0 (0) | N/A |
| Diabetic foot ulcer – diagnosis and surgery codesd | |||
| E10.5-E14.5 (DM with peripheral vascular complication) | N/A | N/A | 26 (49) |
| L97 (ulcer of lower limb) | N/A | N/A | 4 (8) |
| L98.4 (chronic skin ulcer, non specified) | N/A | N/A | 5 (9) |
| R02 (gangrene) | N/A | N/A | 0 (0) |
| M86 (osteomyelitis) | N/A | N/A | 1 (2) |
| KQDA (puncture, incisions and local destructions of pathological tissue in the skin at the lower extremity) | N/A | N/A | 2 (4) |
| KQDB (treatment of ulcer at lower extremity) | N/A | N/A | 24 (45) |
| KQDG (operations for chronic ulcer/fistula at lower extremity) | N/A | N/A | 2 (4) |
Notes: aOne patient was discharged with an A- and a B-diagnosis that were both included in the polyneuropathy algorithm. Thus the percentage does not sum up to 100%. bOne patient was discharged with 2 different codes, that were both included in the in polyneuropathy algorithm. c39 patients had redeemed prescriptions of one type of ATC-code, 10 patients had redeemed prescriptions of two types of ATC-codes, 3 patents had redeemed prescriptions of three types of ATC-codes and 1 had redeemed prescriptions of five different types of ATC-codes. dEach patient may have been given one or more diagnosis codes and/or one or more surgery codes on the diabetic foot ulcer date.
Abbreviations: DPN; Diabetic polyneuropathy, ICD-10; International classification of diseases, version 10, DNPR; Danish National Patient Register, DHSPR; Danish Health Service Prescription Register, N/A; Not applicable, e.g. diabetic foot ulcer-defining codes not relevant for polyneuropathy groups and neuropathic pain treatment codes and polyneuropathy-defining codes not relevant for diabetic foot ulcer group.