Table 3.
Gene set enrichment analysis for METTL3 with KEGG pathway gene sets gene symbols using the TCGA and GSE14520 datasets
| KEGG pathways | TCGA | GSE14520 | ||||
|---|---|---|---|---|---|---|
| NES | P-value | FDR q-value | NES | P-value | FDR q-value | |
| KEGG_SPLICEOSOME | 2.28 | ＜0.001 | ＜0.001 | 2.57 | ＜0.001 | ＜0.001 |
| KEGG_CELL_CYCLE | 2.02 | ＜0.001 | 0.0023 | 2.59 | ＜0.001 | 0.0023 |
| KEGG_DNA_REPLICATION | 1.85 | 0.0014 | 0.0108 | 2.53 | 0.0014 | 0.0108 |
| KEGG_BASAL_TRANSCRIPTION_FACTORS | 1.75 | 0.0014 | 0.0254 | 1.67 | 0.0014 | 0.0254 |
| KEGG_HOMOLOGOUS_RECOMBINATION | 1.72 | 0.0073 | 0.0250 | 1.67 | 0.0073 | 0.0250 |
| KEGG_BASE_EXCISION_REPAIR | 1.69 | 0.0028 | 0.0265 | 2.03 | 0.0028 | 0.0265 |
| KEGG_RNA_DEGRADATION | 1.66 | 0.0055 | 0.0312 | 1.91 | 0.0055 | 0.0312 |
Abbreviation: NES, normalized enrichment score.