Table 4.
MICs of Imipenem (IPM), Ertapenem (ETP), and Meropenem (MEM) with and without the β-lactamase inhibitors (βLI) against the tested isolates.
| Gene of resistance | Isolate ID | MIC (μg/mL) | |||||
|---|---|---|---|---|---|---|---|
| IPM | IPM + βLI | ETP | ETP + βLI | MEM | MEM + βLI | ||
| blaOXA-48 | IMP 53 | 32 | 0.25 | 128 | 2 | 16 | 0.03125 |
| IMP 57 | 64 | 1 | >256 | 16 | 64 | 0.25 | |
| IMP 197 | >256 | 1 | >256 | 16 | 128 | 1 | |
| IMP 215 | 128 | 0.5 | >256 | 8 | 128 | 0.125 | |
| IMP 223 | 16 | 0.25 | 16 | 0.25 | 2 | 0.03125 | |
| blaNDM-1 | IMP 216 | >256 | 0.5 | >256 | 2 | >256 | 0.5 |
| IMP 217 | 8 | 1 | 1 | 1 | 1 | 0.03125 | |
| blaKPC-2 | KPC | 4 | 1 | 4 | 0.03125 | 4 | 0.03125 |
| blaOXA-23-like, blaOXA-51-like | ACN 2090 | >256 | 32 | >256 | >256 | 128 | 32 |
| ACN 2209 | >256 | 32 | >256 | >256 | 128 | 32 | |
| ACN 2273 | >256 | 8 | >256 | >256 | 128 | 8 | |
| ACN 2285 | >256 | 32 | >256 | >256 | 128 | 32 | |
| ACN 2493 | >256 | 32 | >256 | >256 | 128 | 32 | |
| ACN 3630 | >256 | 8 | >256 | >256 | 128 | 8 | |
The βLI for blaOXA-48, blaOXA-23-like, and blaOXA-51-like is Avibactam. The βLI for blaNDM-1 is Ca-EDTA. The βLI for blaKPC-2 is Relebactam.